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S7451 Sigma-Aldrich

SJ-172550

≥95% (HPLC)

Synonym: 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-acetic acid methyl ester

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Properties

Related Categories Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
InChI Key   RKKFQJXGAQWHBZ-YVLHZVERSA-N
assay   ≥95% (HPLC)
form   powder
color   orange
solubility   DMSO: ≥30 mg/mL
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Application

SJ-172550 may be used in MDMX and p53-mediated cell signaling studies.

Biochem/physiol Actions

SJ-17255 is a MDMX inhibitor. Similarly to MDM2, MDMX regulates p53. But in contrast to MDM2, MDMX appears to directly regulate p53 transcription. SJ-172550 is a first small-molecule inhibitor of MDMX with a low micromolar binding constant. It appears that SJ-172550 is binding to the p53-binding pocket of MDMX, thus liberating p53 to induce apoptosis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


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Protocols & Articles
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