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S7936 Sigma-Aldrich

SB 205384

solid

Synonym: 4-Amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-b]pyridine-3-carboxylic acid but-2-ynyl ester

  • CAS Number 160296-13-9

  • Empirical Formula (Hill Notation) C17H18N2O3S

  • Molecular Weight 330.40

  •  MDL number MFCD00918851

  •  PubChem Substance ID 24278711

  •  NACRES NA.77

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Properties

Related Categories Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
form   solid
color   off-white
solubility   DMSO: 18 mg/mL
  H2O: insoluble
SMILES string   CC#CCOC(=O)c1c(C)nc2sc3CC(O)CCc3c2c1N
InChI   1S/C17H18N2O3S/c1-3-4-7-22-17(21)13-9(2)19-16-14(15(13)18)11-6-5-10(20)8-12(11)23-16/h10,20H,5-8H2,1-2H3,(H2,18,19)
InChI key   JDTZAGLGBRRCJT-UHFFFAOYSA-N

Description

Application

SB 205384 was used to study GABA-gated currents in rat locus coeruleus neurons.6

Biochem/physiol Actions

SB 205384 is a selective and positive allosteric modulator of non-benzodiazepine site of the GABAA receptor.3 It affects the extrasynaptic GABAA receptors in rat cortical neurons4 and enhances the GABAergic transmission onto pro-opiomelanocortin neurons in mice.5

GABAA receptor modulator selective for the α3β2γ2 subunit combination.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

Manufactured and sold under license from GlaxoSmithKline Pharmaceuticals

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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