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S8195 Sigma-Aldrich

Swainsonine

from Metarrhizium anisopliae, ≥98% (TLC)

Synonym: (1S,2R,8R,8aR)-1,2,8-Octahydroindolizidinetriol

  • CAS Number 72741-87-8

  • Empirical Formula (Hill Notation) C8H15NO3

  • Molecular Weight 173.21

  •  Beilstein/REAXYS Number 4175740

  •  MDL number MFCD00017554

  •  PubChem Substance ID 24899779

  •  NACRES NA.85

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antibiotics by Mechanism of Action,
Quality Level   200
biological source   Metarrhizium anisopliae
assay   ≥98% (TLC)
form   lyophilized powder
color   white to faint yellow
solubility   H2O: soluble 1 mg/mL
Mode of action   enzyme | inhibits
antibiotic activity spectrum   neoplastics
storage temp.   2-8°C
SMILES string   O[C@@H]1CCCN2C[C@@H](O)[C@@H](O)C12
InChI   1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7?,8-/m1/s1
InChI key   FXUAIOOAOAVCGD-DCDLSZRSSA-N

Description

Application

Swainsonine is an indolizidine alkaloid from the plant Metarrhizium anisopliae that is used as a potent α-mannosidase inhibitor. Product S8195 has been used in chemical inhibition assays of CHO Lec2 cells to inhibit glycosylation .

Swainsonine is a potent inhibitor of various α-mannosidases, especially of α-mannosidase II. It inhibits glycoprotein processing and also acts as immune modulator.

Biochem/physiol Actions

Swainsonine is a potent α-mannosidase inhibitor. It also has antimetastatic, antiproliferative, and immunomodulatory activity . It also inhibits glycoprotein processing.

Packaging

1MG

Preparation Note

Soluble in water, methanol, DMSO

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
NM2408666
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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