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S8201 Sigma-Aldrich

SR-3576

≥98% (HPLC)

Synonym: 3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide, 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide

  • CAS Number 1164153-22-3

  • Empirical Formula (Hill Notation) C27H27N5O5

  • Molecular Weight 501.53

  •  MDL number MFCD18632556

  •  PubChem Substance ID 329824599

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, S
InChI Key   MTFAYLZZDJGFGV-UHFFFAOYSA-N
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   light brown to brown
solubility   DMSO: ≥20 mg/mL
storage temp.   2-8°C

Description

Application

SR-3576 may be used in JNK3-mediated cell signaling studies.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

SR-3576 is a cell-permeable, potent and selective JNK3 (c-Jun N-terminal kinase 3) inhibitor.

SR-3576 is a small molecule inhibitor belonging to aminopyrazole class that selectively inhibits JNK3 with >2800 fold selectively over p38.1

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

MAPKs

The mitogen-activated protein kinase (MAPK) family consists of both stress activated (SAPK) and mitogen-activated (MAPK) protein kinases. They form a network of signal transduction cascades that medi...
Keywords: Anti-inflammatory agents, Apoptosis, Cancer, Cell proliferation, Cellular processes, Clinical, Gene expression, Growth factors, Inflammation, Phosphorylations, Transcription, Transduction, transformation

Peer-Reviewed Papers
15

References

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