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S8567 Sigma-Aldrich

SU 4312

≥98% (HPLC)

Synonym: 3-(4-Dimethylaminobenzylidenyl)-2-indolinone, 3-[[(4-Dimethyl­amino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture

  • CAS Number 5812-07-7

  • Empirical Formula (Hill Notation) C17H16N2O

  • Molecular Weight 264.32

  •  MDL number MFCD00118147

  •  PubChem Substance ID 24278803

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Description

Application

SU 4312 was used to study angiogenesis during development of zebrafish embryos.2

Packaging

5 mg in glass bottle

Biochem/physiol Actions

SU 4312 inhibits the neuronal NOS and exhibits neuroprotection against NO-mediated neurotoxicity. It might be effective in treatment of neurodegenerative disorders.1

SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Other Notes

This product is a mixture of the cis- and trans- isomers. The ratio is about 55:45 based on HPLC.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cytokines & Growth Factors Research

Cytokines and growth factors (GF) are chemical messengers that mediate intracellular communication, thereby regulating cellular and nuclear functions. These chemical messengers bind cell surface rece...
Keywords: Biological processes, Cancer, Cell proliferation, Diseases, Growth factors, Ligands, Phosphorylations, Transcription, Transduction

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activi...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Diseases, Inflammation, Metabolism, Neurodegenerative Diseases, Phosphorylations, Transduction

Peer-Reviewed Papers
15

References

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