S8567 Sigma-Aldrich

SU 4312

≥98% (HPLC)

Synonym: 3-(4-Dimethylaminobenzylidenyl)-2-indolinone, 3-[[(4-Dimethyl­amino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture

  • CAS Number 5812-07-7

  • Empirical Formula (Hill Notation) C17H16N2O

  • Molecular Weight 264.32

  •  MDL number MFCD00118147

  •  PubChem Substance ID 24278803




SU 4312 was used to study angiogenesis during development of zebrafish embryos.2


5 mg in glass bottle

Biochem/physiol Actions

SU 4312 inhibits the neuronal NOS and exhibits neuroprotection against NO-mediated neurotoxicity. It might be effective in treatment of neurodegenerative disorders.1

SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Other Notes

This product is a mixture of the cis- and trans- isomers. The ratio is about 55:45 based on HPLC.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles


Discover Bioactive Small Molecules for Cytokines & Growth Factors Research

Cytokines and growth factors (GF) are chemical messengers that mediate intracellular communication, thereby regulating cellular and nuclear functions. These chemical messengers bind cell surface rece...
Keywords: Biological processes, Cancer, Cell proliferation, Diseases, Growth factors, Ligands, Phosphorylations, Transcription, Transduction

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activi...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Diseases, Inflammation, Metabolism, Neurodegenerative Diseases, Phosphorylations, Transduction

Peer-Reviewed Papers


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