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S9820 Sigma-Aldrich

SU 11274

≥98% (HPLC), powder

Synonym: (3Z)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology,
InChI Key   FPYJSJDOHRDAMT-KQWNVCNZSA-N
assay   ≥98% (HPLC)
form   powder
color   orange
solubility   DMSO: 10 mg/mL at 60 °C
  H2O: insoluble
storage temp.   2-8°C

Description

Application

SU 11274 was used to inhibit c-Met in non-small cell lung cancer cell lines.3

SU11274 has been used:
• To study the role of hepatocyte growth factor (HGF) in human vestibular schwannoma proliferation.
• To study its effect on human gastric carcinoma cell line MKN-45.
• To study the effect of HGF on phosphorylation of epidermal growth factor receptor, c-Met and other signaling pathways.

Biochem/physiol Actions

SU 11274 is a class I c-Met inhibitor that competes with ATP to bind to the activation loop of c-Met.1 Inhibition of c-Met by SU 11274 is effective in improving the clinical outcome in non-small cell lung cancer cell lines.2

c-Met kinase is a hepatocyte growth factor, involved in tumor invasion process and thus it serves as therapeutic target for cancer. It is found that SU11274 showed decreased tumor progression in human melanoma, by reducing tumor growth and metastasis.

SU 11274 is a Met tyrosine kinase inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activi...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Diseases, Inflammation, Metabolism, Neurodegenerative Diseases, Phosphorylations, Transduction

Peer-Reviewed Papers
15

References

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