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SAB4200754 Sigma-Aldrich

Anti-IL6 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-B-cell stimulatory factor 2 (BSF-2), Anti-CTL differentiation factor (CDF), Anti-Hybridoma growth factor, Anti-Interferon beta-2 (IFN-beta-2), Anti-Interleukin-6

  •  NACRES NA.41

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Properties

clone   polyclonal
biological source   rabbit
application(s)   immunoblotting: 1:2,000-1:4,000 using human osteosarcoma MG-63 concentrated supernatant treated with IL1ß
  immunoprecipitation (IP): 1-2.5 μL using human osteosarcoma MG-63 concentrated supernatant treated with IL1ß
species reactivity   human
mol wt   ~23 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   IgG fraction of antiserum
Quality Level   200
antibody product type   primary antibodies
concentration   ~1.0 mg/mL
UniProt accession no.   P05231
Gene Information   human ... IL6(3569)

Description

General description

Interleukin-6 (IL6) is a multifunctional cytokine. The gene is located on the human chromosome at 7p15.3. IL6 is found in many supplemental cloning media.

Immunogen

recombinant IL6

Application

Anti-IL6 antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Biochem/physiol Actions

Interleukin-6 (IL6) plays a wide variety of biological roles in the immune , nervous and endocrine systems. It is involved as a primary regulator of acute and chronic inflammatory diseases. IL6 is a target for clinical treatment against autoimmune disorders such as rheumatoid arthritis, juvenile idiopathic arthritis and Castleman′s disease. It also plays a key role in the pathogenesis of myeloma. IL6 levels are higher in patients with different kinds of malignant disease. Elevated circulating levels of IL6 is considered as a biomarker for acute coronary syndrome (ACS), cardiovascular diseases, such as heart attack and stroke and unstable angina. It is an essential component of hybridoma growth.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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Antibodies are a critical part of COVID-19 research as they are used to gain insight into the immune system response to SARS-CoV-2 infections. Relevant applications of antibodies include the detectio...
Keywords: Atomic absorption spectroscopy, Clinical, Clinical Chemistry, Diagnostic, Electron capture detector, Enzyme-linked immunosorbent assay, Gastrointestinal, Immunoassay, Immunohistochemistry, Immunology, Indicators, Individual protein Immunoprecipitation, Microscopy, PAGE, Purification, Reductions, Respiratory, Therapeutic uses, Western blot

Peer-Reviewed Papers
15

References

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