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SAB4200763 Sigma-Aldrich

Anti-Dystrophin antibody, Mouse monoclonal

clone MANDRA1, purified from hybridoma cell culture

Synonym: Anti-DMD

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Properties

clone   MANDRA1, monoclonal
biological source   mouse
application(s)   immunoblotting: suitable
  immunofluorescence: suitable
  immunohistochemistry: 10-20 μg/mL using acetone fixed rat tongue frozen sections
species reactivity   rat, mouse, human, zebrafish
mol wt   ~427 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
isotype   IgG1
Quality Level   200
antibody product type   primary antibodies
concentration   ~1.0 mg/mL
UniProt accession no.   P11532
Gene Information   human ... DMD(1756)

Description

General description

Anti-Dystrophin antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the MANDRA1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Dystrophin is a rod-shaped cytoskeletal protein located to the periphery (plasma membrane) of normal striated muscle fibers.

Application

Anti-Dystrophin antibody, Mouse monoclonal has been used in:
• immunohistochemistry
• immunoblotting immunofluorescence
• ELISA

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Biochem/physiol Actions

Dystrophin is absent, reduced or altered because of mutation in Duchenne and Becker muscular dystrophies (DMD/BMD) or in its homologue in mouse. Severe DMD is associated with a marked Dystrophin deficiency whereas patients with the milder form of BMD show less pronounced abnormalities of protein expression.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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