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SAB4200780 Sigma-Aldrich

Anti-Human IgM (μ-chain specific) antibody, Mouse monoclonal

clone MB-11, purified from hybridoma cell culture

Synonym: Anti-Human immunoglobulin M

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Properties

biological source   mouse
antibody product type   primary antibodies
clone   MB-11, monoclonal
form   buffered aqueous solution
species reactivity   human
concentration   ~1.0 mg/mL
application(s)   ELISA: 0.1-0.2 μg/mL using 2.5 μg/mL Human IgM myeloma for coating
  immunoblotting: suitable
isotype   IgG2b
shipped in   dry ice
storage temp.   −20°C

Description

General description

Immunoglobulin M (IgM) is the major class of surface immunoglobulins on lymphocyte membranes. IgM is suggested to act as the first line of defense during microbial infections. IgM has a pentameric structure, in which monomers are linking together via disulfide bonds. Surface IgM is expressed on immature and mature B cells, whereas IgM heavy chain is expressed intracellularly in pre-B cells. IgM serves as the antigen receptor of naive B cells and is involved in B cell maturation and complement activation. Anti-Human IgM (m-chain specific) antibody, Mouse monoclonal specifically recognizes m chain of Human IgM. The antibody shows no cross-reactivity with human IgG, Fab, Fc, k, l, and g chains.

Immunogen

Purified human IgM

Application

The antibody is recommended to use in various immunological techniques, including ELISA and Immunoblot.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

Other Notes

This product is for R&D use only, not for drug, household, or other uses.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Protocols & Articles
Peer-Reviewed Papers
15

References

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