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SBR00014 Sigma-Aldrich

Daptomycin Ready Made Solution

1 mg/mL in DMSO

Synonym: N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine[egr]1-lactone

  • CAS Number 103060-53-3

  • Empirical Formula (Hill Notation) C72H101N17O26

  • Molecular Weight 1620.67

  •  MDL number MFCD28968054

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Properties

Related Categories Antibiotic Ready Made Solutions, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Biochemicals and Reagents More...
biological source   Streptomyces roseosporus
description   Ready Made Solution
form   liquid
concentration   1 mg/mL in DMSO
color   colorless to faint yellow
Mode of action   DNA synthesis | interferes
  protein synthesis | interferes
antibiotic activity spectrum   Gram-positive bacteria
shipped in   dry ice
storage temp.   −20°C

Description

Packaging

0.5ML

Preparation Note

The 1 mg/mL solution may be further diluted in an appropriate buffer prior to use. It is recommended that a fresh dilution be made on the day of use.

Biochem/physiol Actions

Daptomycin is a natural cyclic lipopeptide antibiotic found in Streptomyces roseosporus. It is has been found to be effective in treating infections caused by aerobic Gram-positive bacteria. Daptomycin inhibits many antibiotic resistant strains such as methicillin-resistant S. aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA).

The mode of action of daptomycin is quite different from that of any other antibiotic. Daptomycin binds to bacterial membranes and causes a rapid depolarization of membrane potential. This loss of membrane potential causes inhibition of protein, DNA, and RNA synthesis, which results in bacterial cell death.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles
Peer-Reviewed Papers
15

References

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