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SMB00607 Sigma

Amoxicillin trihydrate: potassium clavulanate (4:1)

Synonym: Amoxicillin Trihydrate: Potassium Clavulanate

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Properties

form   powder
color   off-white
solubility   water: 1 mg/mL
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Components

Material is a powdered mixture of 4 parts amoxicillin trihydrate to 1 part potassium clavulanate.

Packaging

1G

Biochem/physiol Actions

Amoxicillin trihydrate is a broad-spectrum, β-lactam antibiotic. It inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria. Since amoxicillin is degraded by β-lactamases, it does not show activity against bacteria which produce these enzymes.

Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases found in bacteria that are resistant to penicillins and cephalosporins.

Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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