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SMB00704 Sigma

Lipopolysaccharides from Proteus mirabilis

purified by phenol extraction

Synonym: LPS

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Properties

Related Categories Biochemicals and Reagents, Carbohydrates, Carbohydrates A to Z, Carbohydrates H-L, Complex Lipids,
form   lyophilized powder
purified by   phenol extraction
storage temp.   2-8°C

Description

Preparation Note

Soluble in water and cell culture medium DMEM (1 mg/mL) yielding a clear to slightly hazy solution.

Biochem/physiol Actions

Lipopolysaccharide (LPS) and its lipid A moiety stimulate cells of the innate immune system by the toll-like receptor 4 (TLR4), a member of the toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs). Lipid A plays a role in the biological properties attributed to endotoxic LPS. LPS is a highly immunogenic antigen which has the ability to enhance immune responses.

Proteus mirabilis is a Gram-negative facultative anaerobic rod-shaped bacterium. Bacteria of the genus Proteus of the family Enterobacteriaceae are opportunistic human pathogens responsible for wound and burn infections as well as skin, eye, ear, nose, throat, urinary tract, and gastrointestinal infections and bacteremias. The most common infection involving P. mirabilis occurs when the bacteria, which is a member of the natural intestinal flora, moves to the urethra and urinary bladder causing urinary tract infection.

The outer-membrane lipopolysaccharide is considered an important virulence factor of Proteus. It has been suggested that the immunological response against P.mirabilis LPS might play a role in rheumatoid arthritis. A possible correlation between the abundance of P.mirabilis in the intestine and obesity was suggested recently. The purified LPS from P. mirabilis OXK is used in the Weil-Felix test for the diagnosis of rickettsiosis (scrub typhus) caused by the bacterium Orientia (Rickettsia) tsutsugamushi.

General description

Lipopolysaccharides (LPS′s) are are complex glycolipids that are characteristic components of the cell wall of Gram-negative bacteria. They consist of a lipid A moiety linked to an antigenic O-polysaccharide.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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