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SML0014 Sigma-Aldrich

Scutellarin hydrate

≥98% (HPLC)

Synonym: 5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl-ß-D-glucopyranosiduronic acid hydrate, 7-(β-D-Glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one hydrate, Breviscapin, Scutellarein-7-O-β-D-glucuronide

  • Empirical Formula (Hill Notation) C21H18O12 · xH2O

  • Molecular Weight 462.36 (anhydrous basis)



Biochem/physiol Actions

Scutellarin is a flavonoid that exhibits a number of cardio- and neuro-protective effects. Scutellarin inhibits p38 activity, ERK phosphorylation, and TGF-β expression and fibrosis in a rat myocardial infarct model. In a cerebral ischemia-reperfusion model, the compound reduced infarct volume and neurological deficits by increasing eNOS expression while inhibiting the induction of iNOS.


5, 25 mg in glass bottle


Scutellarin hydrate may be used in MAPK-mediated cell signaling studies.

Features and Benefits

This compound is featured on the MAPKs and Nitric Oxide Synthases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Milli-Q® Water Purification Solutions
Protocols & Articles



The mitogen-activated protein kinase (MAPK) family consists of both stress activated (SAPK) and mitogen-activated (MAPK) protein kinases. They form a network of signal transduction cascades that medi...
Keywords: Anti-inflammatory agents, Apoptosis, Cancer, Cell proliferation, Cellular processes, Clinical, Gene expression, Growth factors, Inflammation, Phosphorylations, Transcription, Transduction, transformation

Nitric Oxide Synthases

Nitric oxide is a reactive free radical gas that can act as an intracellular or extracellular messenger. It may act locally as an autacoid, paracrine substance or neurotransmitter, and at a distant t...
Keywords: Adhesion, Angiogenesis, Antimicrobials, Biological processes, Cell signaling, Gene expression, Inflammation, Metabolism, Myristoylations, Neurotransmission, Neurotransmitters, Oxidations, Palmitoylations, Phosphorylations

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