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SML0018 Sigma-Aldrich

PG01037 dihydrochloride hydrate

≥98% (HPLC)

Synonym: N-[(2E)-4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]-2-buten-1-yl]-4-(2-pyridyl)benzamide dihydrochloride hydrate, N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate

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Properties

Related Categories Antagonists - Dopaminergics, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
color   white to tan
solubility   H2O: ≥8 mg/mL at ~60 °C
storage temp.   2-8°C
SMILES string   O.Cl.Cl.Clc1cccc(N2CCN(CC2)C\C=C\CNC(=O)c3ccc(cc3)-c4ccccn4)c1Cl
InChI   1S/C26H26Cl2N4O.2ClH.H2O/c27-22-6-5-8-24(25(22)28)32-18-16-31(17-19-32)15-4-3-14-30-26(33)21-11-9-20(10-12-21)23-7-1-2-13-29-23;;;/h1-13H,14-19H2,(H,30,33);2*1H;1H2/b4-3+;;;
InChI key   GGTFHRPUVRVPDZ-FHJHGPAASA-N

Description

Application

PG01037 dihydrochloride hydrate may be used in dopamine D3-mediated cell signaling studies.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

PG01037 dihydrochloride is a selective dopamine D3 receptor antagonist. It is more selective for D3 receptors than other D3 antagonists that are currently available with a D2/D3 selectivity ratio of 867and a D4/D3 selectivity ratio of 13,000.

Selective dopamine D3 receptor antagonist

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Dopamine Receptors

Dopamine receptors were initially differentiated into two major types based on the ability of dopamine to stimulate (D1) or inhibit (D2) adenylyl cyclase activity and produce the second-messenger mol...
Keywords: Atomic absorption spectroscopy, Dopamine agents, Gene expression, Genetic, Genetics, Ligands, Methylations, Parkinson Disease, Schizophrenia, Transduction

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