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SML0077 Sigma-Aldrich

VU591

≥98% (HPLC)

Synonym: 2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole), 2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole), 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole

  • CAS Number 1222810-74-3

  • Empirical Formula (Hill Notation) C16H12N6O5

  • Molecular Weight 368.30

  •  PubChem Substance ID 329825139

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
InChI Key   ZQPXNYLXYNRFNP-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to tan
solubility   DMSO: ≥12 mg/mL
storage temp.   2-8°C
Gene Information   human ... KCNJ1(3758)

Description

Application

VU591 may be used in cell signaling studies.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Making Headway

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Protocols & Articles

Articles

Potassium Channels

Potassium channels are essential in both excitable and non-excitable cells for the control of membrane potential, regulation of cell volume, and the secretion of salt, neurotransmitters and hormones....
Keywords: Absorption, Cancer, Cell proliferation, Cell signaling, Diabetes, Diseases, Hormones, Ligands, Neurotransmitters, Phosphorylations, Sequencing

Peer-Reviewed Papers
15

References

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