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SML0088 Sigma-Aldrich

WZ811

≥98% (HPLC)

Synonym: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

  • CAS Number 55778-02-4

  • Empirical Formula (Hill Notation) C18H18N4

  • Molecular Weight 290.36

  •  MDL number MFCD18086914

  •  PubChem Substance ID 329825148

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemokine Inhibitors,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to tan
solubility   DMSO: ≥7 mg/mL
storage temp.   2-8°C
SMILES string   C(Nc1ccccn1)c2ccc(CNc3ccccn3)cc2
InChI   1S/C18H18N4/c1-3-11-19-17(5-1)21-13-15-7-9-16(10-8-15)14-22-18-6-2-4-12-20-18/h1-12H,13-14H2,(H,19,21)(H,20,22)
InChI key   KBVFRXIGQQRMEF-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

WZ811 is a potent, specific antagonist of CXCR4 (IC50 = 0.3 nM). WZ811 blocks SDF-1 mediated changes in cellular cAMP levels in U87 glioma cells (IC50 = 1.2 nM) and Matirgel infiltration of MDA-MB-231 cells (IC50 = 5.2 nM).

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cytokines & Growth Factors Research

Cytokines and growth factors (GF) are chemical messengers that mediate intracellular communication, thereby regulating cellular and nuclear functions. These chemical messengers bind cell surface rece...
Keywords: Biological processes, Cancer, Cell proliferation, Diseases, Growth factors, Ligands, Phosphorylations, Transcription, Transduction

Peer-Reviewed Papers
15

References

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