• USA Home
  • SML0128 - M30 dihydrochloride

SML0128 Sigma-Aldrich

M30 dihydrochloride

≥98% (HPLC)

Synonym: 5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride, M-30 dihydrochloride, VAR10300 dihydrochloride

  • CAS Number 64821-19-8

  • Empirical Formula (Hill Notation) C14H14N2O · 2HCl

  • Molecular Weight 299.20

  •  MDL number MFCD20488063

  •  PubChem Substance ID 329825178

  •  NACRES NA.77



Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   green-yellow
solubility   DMSO, heptane and xylene: ≥21 mg/mL
storage temp.   2-8°C
SMILES string   Cl.Cl.CN(CC#C)Cc1ccc(O)c2ncccc12
InChI   1S/C14H14N2O.2ClH/c1-3-9-16(2)10-11-6-7-13(17)14-12(11)5-4-8-15-14;;/h1,4-8,17H,9-10H2,2H3;2*1H



M30 dihydrochloride may be used in monamine oxidase-mediated cell signaling studies.


5, 25 mg in glass bottle

Biochem/physiol Actions

M30 is a site-activated iron chelator and monoamine oxidase (MAO) inhibitor; with neuroprotective and anti-apoptotic activity. It is a multifunctional non-toxic, brain permeable iron chelator possessing a neuroprotective propargylamine moiety and an antioxidant-iron chelator moiety. M30 is a selective irreversible inhibitor of mitochondrial brain monoamine oxidases A and B (MAO-A and -B), providing for improved levels of neurotransmitters. It reduces oxidative damage and shows neuroprotective and neurorestorative effects in various neurodegenerative models of ALS, Alzheimer′s and Parkinson′s diseases, and is being investigated in other diseases where oxidative stress is a problem.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles


Dopamine and Norepinephrine Metabolism

While reuptake of catecholamines plays an important role in regulating their synaptic levels, metabolism also contributes significantly to the termination of catecholamine neurotransmission. The rela...
Keywords: Atomic layer deposition, Clinical, Dopamine agents, Metabolism, Metabolites, Neurotransmission, Parkinson Disease

Histamine Synthesis and Metabolism

Histamine is a biogenic amine that stimulates multiple histamine receptor types. In mammals, histamine is found within granules of basophils and mast cells (>90% of body stores) and within tuberomamm...
Keywords: Atomic layer deposition, Cardiovascular, Ligands, Metabolism, Methylations, Microwave synthesis, Oxidations

Serotonin Synthesis and Metabolism

Serotonin (5-hydroxytryptamine) is principally found stored in three main cell types - i) serotonergic neurons in the CNS and in the intestinal myenteric plexus, ii) enterochromaffin cells in the muc...
Keywords: Anti-depressants, Catalysis, Clinical, Decarboxylations, Dopamine agents, Gastrointestinal, Hormones, Metabolism, Metabolites, Oxidations

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?