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SML0150 Sigma-Aldrich

Tolcapone

≥98% (HPLC)

Synonym: 3,4-Dihydroxy-4′-methyl-5-nitrobenzophenone, Ro 40-7592

  • CAS Number 134308-13-7

  • Empirical Formula (Hill Notation) C14H11NO5

  • Molecular Weight 273.24

  •  MDL number MFCD00866569

  •  PubChem Substance ID 329825198

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Catechol-O-methyltransferase, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   yellow
solubility   DMSO: ≥15 mg/mL
originator   Roche
storage temp.   2-8°C
SMILES string   Cc1ccc(cc1)C(=O)c2cc(O)c(O)c(c2)[N+]([O-])=O
InChI   1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3
InChI key   MIQPIUSUKVNLNT-UHFFFAOYSA-N
Gene Information   human ... COMT(1312)

Description

Application

Tolcapone may be used in COMT-mediated cell signaling studies.
Tolcapone has been used in methyltransferase assay in human embryonic kidney 293 cells.

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Inhibition of catechol-O-methyltransferase by tolcapone increases the half-life and bioavailabilty of levodopa. It therefore is an effective adjunctive therapy in patients with Parkinson′s disease with motor response fluctuations.

Tolcapone is an orally active catechol-O-methyltransferase (COMT) inhibitor. It inhibits both central and peripheral COMT. Tolcapone crosses the blood-brain barrier, and has been used for L-DOPA adjunct therapy in the treatment of Parkinson′s Disease.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
RTECS 
PC4952500
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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