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SML0207 Sigma-Aldrich

SB 328437

≥98% (HPLC)

Synonym: L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester

  • CAS Number 247580-43-4

  • Empirical Formula (Hill Notation) C21H18N2O5

  • Molecular Weight 378.38

  •  MDL number MFCD16618397

  •  PubChem Substance ID 329825229

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to tan
solubility   DMSO: ≥10 mg/mL
originator   GlaxoSmithKline
storage temp.   2-8°C
SMILES string   COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c2cccc3ccccc23
InChI   1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
InChI key   VMFGCGRAIBLAFY-IBGZPJMESA-N

Description

Application

SB 328437 may be used to study CCR3-mediated cell signaling in asthma models.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.

SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM.

Features and Benefits

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Chemokine Receptors

Chemokines are a family of low molecular weight secreted proteins that act as leukocyte specific chemoattractants, although they may have additional immunological and non-immunological activities. Th...
Keywords: Adhesion, Angiogenesis, Apoptosis, Atomic absorption spectroscopy, Cancer, Cardiovascular, Gene expression, Genetic, Individual protein Immunoprecipitation, Inflammation, Ligands, Peptide synthesis, Transduction

Discover Bioactive Small Molecules for Cytokines & Growth Factors Research

Cytokines and growth factors (GF) are chemical messengers that mediate intracellular communication, thereby regulating cellular and nuclear functions. These chemical messengers bind cell surface rece...
Keywords: Biological processes, Cancer, Cell proliferation, Diseases, Growth factors, Ligands, Phosphorylations, Transcription, Transduction

Peer-Reviewed Papers
15

References

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