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SML0598 Sigma-Aldrich

SDZ 220-581 hydrochloride

≥98% (HPLC)

Synonym: (S)-α-Amino-2-chloro-5-(phosphonomethyl)[1,1-biphenyl]-3-propanoic acid hydrochloride

  • CAS Number 179411-93-9

  • Empirical Formula (Hill Notation) C16H17ClNO5P · HCl

  • Molecular Weight 406.20

  •  MDL number MFCD28124389

  •  PubChem Substance ID 329825568

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids,
InChI Key   WSYIMHDAUSNYSF-RSAXXLAASA-N
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D -5 to -8°, c = 1 in 1 M HCl
color   white to beige
solubility   DMSO: 5 mg/mL, clear (warmed)
storage temp.   room temp

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

SDZ 220-581 is a competitive NMDA receptor antagonist that penetrates the blood brain barrier. ISDZ 220-581 selectively blocks the glutamate recognition-site of the NMDA receptor and reduces prepulse inhibition (PPI). SDZ 220-581 reduces prepulse inhibition (PPI) and has an ED50 of less than 3.2 mg/kg for protection against MES-induced seizures.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


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