EMAIL THIS PAGE TO A FRIEND
SML0941 Sigma-Aldrich

Tibolone

≥98% (HPLC)

Synonym: (7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one, 17-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-3-one, 5(10)-Estren-7α-methyl-17α- ethynyl-17β- ol-3-one

  • CAS Number 5630-53-5

  • Empirical Formula (Hill Notation) C21H28O2

  • Molecular Weight 312.45

  •  EC Number 227-069-1

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones,
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D +100 to +110°, c = 0.5 in chloroform-d
drug control   regulated under CDSA - not available from Sigma-Aldrich Canada
color   white to beige
mp   165-169 °C
solubility   DMSO: 15 mg/mL, clear
storage temp.   2-8°C

Description

General description

Tibolone is a synthetic steroid with weak estrogenic, androgenic, and progestogenic activity used in the treatment of menopausal syndrome. Tibolone and its metabolites induce prolactin production in human endometrial stromal cells in vitro. Sulfation plays a major role in the metabolism and regulation of the tissue-specific activity of tibolone and its metabolites.

Packaging

50 mg in glass bottle

Biochem/physiol Actions

Tibolone is a selective tissue estrogenic activity regulator (STEAR) used for the treatment of the symptoms associated with menopause and also for the treatment of osteoporosis. Tibolone has estrogenic, progestogenic, and/or androgenic activity depending on the tissue. Three major metabolites of tibolone are responsible for its tissue selective mechanism of action. Conversion into 3α- and 3β-hydroxy-tibolone results in estrogenic effects in brain, vagina, and bone. The Δ4 isomer has progestrogenic and androgenic effects and does not cause estrogenic stimulation in the endometrium.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?