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SML0969 Sigma-Aldrich

Inauhzin

≥98% (HPLC)

Synonym: 1-(10H-Phenothiazin-10-yl)-2-(5H-1,2,4-triazino[5,6-b]indol-3-ylthio)-1-butanone, 10-[2-(5H-[1,2,4]Triazino[5,6-b]indol-3-ylthio)butanoyl]-10H-phenothiazine, INZ

  • CAS Number 309271-94-1

  • Empirical Formula (Hill Notation) C25H19N5OS2

  • Molecular Weight 469.58

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to light brown
solubility   DMSO: 5 mg/mL, clear (warmed)
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Inauhzin is a cell-permeable, selective inhibitor of SirT1, which effectively reactivates p53 by inhibiting SIRT1 activity. Inauhzin inhibits cell proliferation, induces senescence, and p53-dependent apoptosis of human cancer cells without apparent toxicity to normal cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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