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SML0986 Sigma-Aldrich

Divin

≥98% (HPLC)

Synonym: 2-[(2-Hydroxy-1-naphthalenyl)methylene]hydrazide-2-methyl-1H-Benzimidazole-1-propanoic acid, N′-[(E)-(2-Hydroxynaphthalen-1-yl)methylidene]-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide)

  • CAS Number 1443321-11-6

  • Empirical Formula (Hill Notation) C22H20N4O2

  • Molecular Weight 372.42

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C

Description

General description

Divin is formed by minicell locus C (minC) and minD gene products. Divin is a nonspecific inhibitor of septation. It has an ability to inhibit cell division at all potential division sites.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Divin (DIVision Inhibitor) is an inhibitor of bacterial division with a novel mechanism of action. During bacterial division, more than a dozen different proteins assemble at the division site in a specific order to form a complex called the divisome, with the first protein, FtsZ , followed by ‘early’ or ‘late’ proteins based on their temporal localization. Divin blocks cell division by disrupting the spatial and temporal localization of the late division proteins, disrupting their assembly and preventing compartmentalization of the cytoplasm. Divin has been found to be a potent bacteriostatic agent against clinical pathogens with low toxicity against mammalian cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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