EMAIL THIS PAGE TO A FRIEND
SML1056 Sigma-Aldrich

CX4338

≥98% (HPLC)

Synonym: 4,4-Dimethyl-6-oxo-N-phenyl-2-[(phenylmethyl)amino]-1-cyclohexene-1-carbothioamide

  • CAS Number 41609-06-7

  • Empirical Formula (Hill Notation) C22H24N2OS

  • Molecular Weight 364.50

  •  NACRES NA.77

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 5 mg/mL, clear (warmed)
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CX4338 is a CXCR2 receptor antagonist. In cell based assays, CX4338 blocks CXCL8-induced receptor internalization and β-arrestin recruitment, but enhances G-protein-mediated signaling events such as calcium mobilization and ERK phosporylation. The comopund inhibits CXCL8-induced neutrophil chemotaxis, and LPS-induced PMN migration in a mouse airway inflammaiton model.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cytokines & Growth Factors Research

Cytokines and growth factors (GF) are chemical messengers that mediate intracellular communication, thereby regulating cellular and nuclear functions. These chemical messengers bind cell surface rece...
Keywords: Biological processes, Cancer, Cell proliferation, Diseases, Growth factors, Ligands, Phosphorylations, Transcription, Transduction

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?