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SML1326 Sigma-Aldrich

PK-THPP

≥98% (HPLC)

Synonym: 1-[1-[6-([1,1′-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone

  • CAS Number 1332454-07-5

  • Empirical Formula (Hill Notation) C29H32N4O2

  • Molecular Weight 468.59

  •  MDL number MFCD28396418

  •  PubChem Substance ID 329825786

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   H2O: 10 mg/mL, clear
  DMSO: 2 mg/mL, clear (warmed)
storage temp.   2-8°C
SMILES string   O=C(CCC)C(CC1)CCN1C2=C3C(CCN(C(C4=CC=C(C5=CC=CC=C5)C=C4)=O)C3)=NC=N2
InChI   1S/C29H32N4O2/c1-2-6-27(34)23-13-16-32(17-14-23)28-25-19-33(18-15-26(25)30-20-31-28)29(35)24-11-9-22(10-12-24)21-7-4-3-5-8-21/h3-5,7-12,20,23H,2,6,13-19H2,1H3
InChI key   CJZGRIRZVHNUSM-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

PK-THPP is a potent antagonist of tandem pore potassium channel subunit TASK-3 (KCNK9, K2P9.1) with an IC50 value of 35 nM for TASK-3 compared to 303 nM for TASK-1 and with >140 fold selectivity over a wider range of potassium channels. PK-THPP was found to act as a respiratory stimulant, stimulating breathing in isoflurane-anesthetized rats.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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