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SML1361 Sigma-Aldrich

BRD73954

≥98% (HPLC)

Synonym: N-Hydroxy-N′-phenethyl-isophthalamide, N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide, N1-Hydroxy-N3-phenethylisophthalamide

  • CAS Number 1440209-96-0

  • Empirical Formula (Hill Notation) C16H16N2O3

  • Molecular Weight 284.31

  •  MDL number MFCD26383435

  •  PubChem Substance ID 329825816

  •  NACRES NA.77

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Properties

Related Categories B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to light brown
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   ONC(C1=CC(C(NCCC2=CC=CC=C2)=O)=CC=C1)=O
InChI   1S/C16H16N2O3/c19-15(17-10-9-12-5-2-1-3-6-12)13-7-4-8-14(11-13)16(20)18-21/h1-8,11,21H,9-10H2,(H,17,19)(H,18,20)
InChI key   FIHKWEQJEDRIFS-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

BRD73954 is the first discovered histone deacetylase 6/8 dual inhibitor. BRD73954 has an IC50 of 36 nM for the class IIb HDAC6 and 120 nM for the class I HDAC8 with IC450′s ranging from 9 μM to greater than 33 μM for other HDACs.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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