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SML1449 Sigma-Aldrich

G3335

≥98% (HPLC)

Synonym: H-Trp-Glu-OH, L-Tryptophyl-L-glutamic acid, WE

  • CAS Number 36099-95-3

  • Empirical Formula (Hill Notation) C16H19N3O5

  • Molecular Weight 333.34

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to off-white
storage temp.   −20°C

Description

Packaging

50, 250 mg in glass bottle

Biochem/physiol Actions

G3335 ( L-tryptophyl-L-glutamic acid) is a cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist with a Kd value of 8.34 μM for PPARγ and much lower activity at other PPAR subtypes. G3335 reversibly and competitively blocks activation of PPARγ by the PPARγ agonist rosiglitazone, and conversely, in rat astrocyte culture higher levels of rosiglitazone reduced harmful effects induced by G3335. At higher concentration G3335 may act as a PPARα agonist, interacting with the PPARα ligand binding domain with a KD of 120 μM. G3335 is reported to reduce hepatic lipid accumulation in lipid-loaded hepatocytes by activation of PPARα.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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