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SML1461 Sigma-Aldrich

Kyotorphin acetate salt

≥98% (HPLC)

Synonym: (2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid acetate salt, KTP, L-tyrosyl-L-arginine acetate salt, Tyr-Arg acetate salt, Tyrosyl-Arginine acetate salt

  • CAS Number 70904-56-2 (free base)

  • Empirical Formula (Hill Notation) C15H23N5O4 · xC2H4O2

  • Molecular Weight 337.37 (free base basis)

  •  PubChem Substance ID 329825895

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, K,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   H2O: 20 mg/mL, clear
storage temp.   −20°C
SMILES string   NC(NCCC[C@@H](C(O)=O)NC([C@@H](N)CC1=CC=C(O)C=C1)=O)=N.C
InChI   1S/C15H23N5O4.CH4/c16-11(8-9-3-5-10(21)6-4-9)13(22)20-12(14(23)24)2-1-7-19-15(17)18;/h3-6,11-12,21H,1-2,7-8,16H2,(H,20,22)(H,23,24)(H4,17,18,19);1H4/t11-,12-;/m0./s1
InChI key   KTMKVRFTDZZFFE-FXMYHANSSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Kyotorphin is a neuroactive dipeptide (Tyr-Arg) shown to have analgesic, neuroprotective, and neuromodulatory properties. It is synthesized in nerve terminals and found in the brain and in cerebro-spinal fluid (CSF). Kyotorphin indirectly stimulates opioid receptors by releasing methionine enkephalin (met-enkephalin). CSF levels are lower in patients with persistent pain and in patients with Alzheimer’s disease.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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