EMAIL THIS PAGE TO A FRIEND
SML1473 Sigma-Aldrich

Chlorcyclizine

≥98% (HPLC)

Synonym: 1-[(4-Chlorophenyl)(phenyl)methyl]-4-methylpiperazine, 1-[(4-Chlorophenyl)phenylmethyl]-4-methyl-piperazine

  • CAS Number 82-93-9

  • Empirical Formula (Hill Notation) C18H21ClN2

  • Molecular Weight 300.83

  •  MDL number MFCD00056036

  •  PubChem Substance ID 329825905

  •  NACRES NA.77

Purchase

Properties

Related Categories AIDS and Viral Research Reagents, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   oil
color   yellow to orange
storage temp.   2-8°C
SMILES string   ClC(C=C1)=CC=C1C(N2CCN(C)CC2)C3=CC=CC=C3
InChI   1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3
InChI key   WFNAKBGANONZEQ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Chlorcyclizine is a first-generation antihistamine being studied as a potential treatment for hepatitis C. Chlorcyclizine is believed to inhibit an early stage of HCV infection, targeting viral entry into host cells. Chlorcyclizine inihbited the entry of cell culture-produced HCV with an IC50 value 2.3 nM. In human hepatoma cells and primary human hepatocytes, Chlorcyclizine showed a synergistic effect with other hepatitis C drugs such as ribavirin, interferon, telaprevir, boceprevir, sofosbuvir, daclatasvir, and cyclosporin A.

Safety & Documentation

Safety Information

RIDADR 
UN 3077 9 / PGIII

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?