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SML1477 Sigma-Aldrich

MPI-0479605 hydrochloride

≥98% (HPLC)

Synonym: N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine hydrochloride

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents,
InChI Key   BYBIFMLUJUNGNX-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 5 mg/mL, clear (warmed)
storage temp.   −20°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

MPI-0479605 is a potent ATP-competitive inhibitor of the dual-specificity kinase Mps-1, which is essential for maintainence of spindle assembly checkpoint and chromalomal spindle attachment. Treatment of cells with MPI-0479605 causes aberrant mitosis and aneuploidy and inhibits growth of tumor xenografts in vivo. MPI-0479605 has an IC50 value of 1.8 nM.

Safety & Documentation

Safety Information

RIDADR 
UN 2811 6.1 / PGIII

Documents

Certificate of Analysis (COA)

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