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SML1487 Sigma-Aldrich

ABT-089 dihydrochloride

≥98% (HPLC)

Synonym: 2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride, Pozanicline dihydrochloride

  • CAS Number 161416-61-1

  • Empirical Formula (Hill Notation) C11H16N2O · 2HCl

  • Molecular Weight 265.18

  •  PubChem Substance ID 329825916

  •  NACRES NA.77

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Properties

Related Categories A-AM, Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D +20 to +30°, c = 1 in methanol
color   white to beige
solubility   H2O: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   CC1=C(OC[C@@H]2CCCN2)C=CC=N1.[H]Cl.[H]Cl
InChI   1S/C11H16N2O.2ClH/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10;;/h3,5-6,10,13H,2,4,7-8H2,1H3;2*1H/t10-;;/m0../s1
InChI key   UGVSESCRKJTJAK-XRIOVQLTSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

ABT-089 (Pozanicline) is a subtype-selective neuronal nicotinic receptor partial agonist binding primarily to the α4β2 and also α6β2 subtypes. It has been investigated for alleviating symptoms of nicotine withdrawal including cognitive deficits and anxiety.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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