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SML1499 Sigma-Aldrich

LW479

≥98% (HPLC)

Synonym: 6-[2-[2-(3-Bromophenyl)-4-oxo-3-thiazolidinyl]phenoxy]-N-hydroxy-hexanamide

  • CAS Number 1688677-89-5

  • Empirical Formula (Hill Notation) C21H23BrN2O4S

  • Molecular Weight 479.39

  •  PubChem Substance ID 329825923

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   BrC1=CC(C2N(C3=CC=CC=C3OCCCCCC(NO)=O)C(CS2)=O)=CC=C1
InChI   1S/C21H23BrN2O4S/c22-16-8-6-7-15(13-16)21-24(20(26)14-29-21)17-9-3-4-10-18(17)28-12-5-1-2-11-19(25)23-27/h3-4,6-10,13,21,27H,1-2,5,11-12,14H2,(H,23,25)
InChI key   XRAVVAITOQNASO-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

LW479 is a potent histone deacetylase inhibitor (HDACI) that down-regulates EGFR expression. Apparently, LW479 blocks the binding of the transcription factor Sp1 and HDAC1 to the EGFR promoter region. LW479 potently induces cell cycle arrest and apoptosis breast cancer cell lines. Also LW479 suppressed breast tumor growth and pulmonary metastasis in nude mice.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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