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SML1528 Sigma-Aldrich

Iloperidone

≥98% (HPLC)

Synonym: 1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone, Zomaril

  • CAS Number 133454-47-4

  • Empirical Formula (Hill Notation) C24H27FN2O4

  • Molecular Weight 426.48

  •  MDL number MFCD00866688

  •  PubChem Substance ID 329825945

  •  NACRES NA.77

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Properties

Related Categories Antagonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 5 mg/mL, clear
storage temp.   −20°C
InChI   1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3
InChI key   XMXHEBAFVSFQEX-UHFFFAOYSA-N

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Iloperidone targets a selective set of dopamine, serotonin and also norepinephrine receptor subtypes. Like similar atypical antipsychotics, Iloperidone has higher affinity for the 5-HT2A receptor (Ki < 10 nM) than for the D2 receptor (Ki = 10–100) nM). Iloperidone has high affinity for dopamine D3 (Ki < 10 nM) and lower affinity for other serotonin or dopamine subtypes. Unlike most atypical antipsychotics, Iloperidone also has high affinity for norepinephrine alpha1 receptors (Ki < 10 nM) which may contribute to the drug’s efficacy on mood and cognition.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
RTECS 
KM5777850
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

UHPLC Analysis of Iloperidone and Its Primary Metabolite Hydroxyiloperidone on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Iloperidone and Its Primary Metabolite Hydroxyiloperidone on Ascentis® Express C18
Keywords: Central Nervous System, Chromatography, Metabolites, Schizophrenia, Separation

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