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SML1535 Sigma-Aldrich

DMH2

≥98% (HPLC)

Synonym: 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, VU0364849

  • CAS Number 1206711-14-9

  • Empirical Formula (Hill Notation) C27H25N5O2

  • Molecular Weight 451.52

  •  PubChem Substance ID 329825950

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Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

DMH2 is a potent antagonist of the BMP receptor activin receptor-like kinase 3 (ALK3, BMPR-IA) that enhance liver regeneration. DMH2 potently inhibits BMP signaling and induced the greatest reduction of cell growth and expression of Id family members in H1299 non-small cell lung carcinoma cells.

General description

DMH2 is a small molecule, which has ability to inhibit BMP type I receptors. The bone morphogenetic proteins (BMP) signal inhibition further decreases expression of Id proteins in lung cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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