• USA Home
  • SML1559 - Furamidine dihydrochloride

EMAIL THIS PAGE TO A FRIEND
SML1559 Sigma-Aldrich

Furamidine dihydrochloride

≥98% (HPLC)

Synonym: 2,5-Bis(4-amidinophenyl)furan dihydrochloride, 4,4′-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride, DB 75, DB75, NSC 305831, WR199385

  • CAS Number 55368-40-6

  • Empirical Formula (Hill Notation) C18H16N4O · 2HCl

  • Molecular Weight 377.27

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, F,
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   H2O: 1 mg/mL, clear (warmed)
storage temp.   −20°C

Description

Packaging

5 mg in glass bottle

Biochem/physiol Actions

Furamidine (DB75) binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine was originally developed as an anti-parasitic compound for a variety of diseases including Chagas′ disease. Furamidine targets AT rich sequences in trypanosome kinetoplast minicircle DNA (kDNA), resulting in subsequent destruction of the kinetoplast and cell death. Furamidine has also been found to inihbit tyrosyl-DNA phosphodiesterase (Tdp1) and act as a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4μM.

General description

Furamidine dihydrochloride is an analog of the aromatic drug pentamidine and a substrate of the organic cation transporter 1 (OCT1). A number of prodrugs of furamidine dihydrochloride are being synthesised and are in clinical trial stages.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?