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SML1560 Sigma-Aldrich

Azoramide

≥98% (HPLC)

Synonym: N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]-butanamide, N-{2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]ethyl} butanamide

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Properties

Related Categories Antioxidants and Cytoprotectants, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Nitric Oxide and Cell Stress More...
InChI Key   VYBFWKKCWTXCQX-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 30 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It has dual activity: Azoramide improves endoplasmic reticulum (ER) protein-folding ability and stimulates the expression of ER chaperones that protect cells against ER stress. Azoramide was shown to protect cells from death and dysfunction in multiple models of ER stress. It showed antidiabetic activity in two independent mouse models of obesity by improving insulin sensitivity and protecting pancreatic β cell function against ER stress.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis


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Protocols & Articles
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