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SML1562 Sigma-Aldrich

HIV inhibitor 18A

≥98% (HPLC)

Synonym: 18A, N-2,1,3-Benzothiadiazol-4-yl-2-[(4-hydroxyphenyl)methylene]-hydrazinecarboxamide

  • CAS Number 331261-50-8

  • Empirical Formula (Hill Notation) C14H11N5O2S

  • Molecular Weight 313.33

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Properties

Related Categories AIDS and Viral Research Reagents, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

HIV inhibitor 18A is a broad spectrum viral fusion and viral entry inhibitor. HIV entry requires several steps in sequence starting with HIV surface glycoprotein gp120 binding to the CD4 receptor followed by a conformational change in gp120, exposing a second recognition site that binds the co-receptor C-C chemokine receptor (CCR5) on the host cell, eventually resulting in the fusion of HIV and the T cell membranes, allowing entry of the viral core into the cell. HIV inhibitor 18A prevents the surface envelope glycoprotein from fusing with host cells by blocking envelope glycoprotein transitions critical for entry rather than interfering with CD4 or CCR5 binding.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
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