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SML1567 Sigma-Aldrich

MCB-613

≥98% (HPLC)

Synonym: 4-Ethyl-2,6-bis(pyridin-3-ylmethylene)cyclohexanone

  • CAS Number 296792-62-6

  • Empirical Formula (Hill Notation) C20H20N2O

  • Molecular Weight 304.39

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Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. There are three steroid receptor coactivators (SRC) that interact with transcription factors and whose overexpression is assciated with a number of cancers, particularly breast cancer. MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. MCB-613 is a cytotoxic molecule which can kill various human cancer cell lines, like HepG2 (liver), PC-3 (prostate) and MCF-7 (breast) cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
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