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SML1575 Sigma-Aldrich

Cyclosporin H

≥97% (HPLC)

Synonym: 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane, cyclic peptide deriv, 5-(N-Methyl-D-valine)-Cyclosporin A

  • CAS Number 83602-39-5

  • Empirical Formula (Hill Notation) C62H111N11O12

  • Molecular Weight 1202.61

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Properties

Related Categories Antioxidants and Cytoprotectants, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology,
biological source   Tolypocladium inflatum
assay   ≥97% (HPLC)
form   powder
optical activity   [α]/D -100 to -115°, c = 0.5 in methanol
storage condition   desiccated
  protect from light
color   white to beige
storage temp.   −20°C

Description

Packaging

1, 5 mg in glass bottle

Biochem/physiol Actions

Cyclosporin H is a selective inhibitor of formyl peptide receptor-1 (FPR-1) and formyl peptide-induced superoxide formation in neutrophils. Cyclosporin H does not bind cyclophilin or evoke an immunosuppressant response. Cyclosporin H has been reported to inhibit tumor promoting phorbol ester TPA/PMA in mouse skin cells and to inhibit calcium/calmodulin-dependent EF-2 phosphorylation.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
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