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SML1580 Sigma-Aldrich

NSC156529

≥98% (HPLC)

Synonym: 6-Methyl-2-phenyl-10-(phenylthio)-1,2-dihydro-24-anthra[1,9-bc]thiophene chloride, 6-Methyl-2-phenyl-10-(phenylthio)-1H-anthra[1,9-bc]thiophenium chloride, CID 3246498, NSC 156529, NSC-156529

  • CAS Number 41134-88-7

  • Empirical Formula (Hill Notation) C28H21ClS2

  • Molecular Weight 457.05

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 2 mg/mL, clear (warmed)
storage temp.   2-8°C
InChI   1S/C28H21S2.ClH/c1-19-22-14-8-16-25(29-20-10-4-2-5-11-20)27(22)24-18-30(21-12-6-3-7-13-21)26-17-9-15-23(19)28(24)26;/h2-17H,18H2,1H3;1H/q+1;/p-1
InChI key   KLQVNXJBZZWIIV-UHFFFAOYSA-M

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

NSC156529 is a potent inhibitor of Akt/PKB pathway that decreases the proliferation of human cancer cells in vitro, and inhibits tumor growth in a prostate tumor xenograft model. NSC156529 inhibits interaction of PDPK1 and AKT1 by direct binding to PDPK1. NSC156529 increases the differentiation status of cancer cells.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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