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SML1582 Sigma-Aldrich

BMS-3

≥95% (HPLC)

Synonym: N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-cyclopropanecarboxamide

  • CAS Number 1338247-30-5

  • Empirical Formula (Hill Notation) C17H12Cl2F2N4OS

  • Molecular Weight 429.27

  •  NACRES NA.77

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Properties

Related Categories Actin Inhibitors and Probes, B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥95% (HPLC)
form   powder
color   white to light brown
solubility   DMSO: 10 mg/mL, clear
storage temp.   −20°C

Description

General description

LIMK1 (LIM domain kinase 1) belongs to the serine-threonine protein kinases. The gene is mapped to human chromosome 7q11.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

BMS-3 shows cytotoxic effects not related to LIMK, but rather through reduction of the levels of tubulin transcripts and induction of mitotic arrest.

It is a specific inhibitor of LIMK1. LIMK1 is responsible for the inactivation of cofilin (ADF family protein), leading to actin reorganization. It is upregulated in several invasive cancers.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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