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SML1585 Sigma-Aldrich

ML116

≥95% (HPLC)

Synonym: 4-Benzyl-1-{thieno[2,3-d]pyrimidin-4-yl}piperidine, 4-[4-(Phenylmethyl)-1-piperidinyl]-thieno[2,3-d]pyrimidine, CID 2100018

  • CAS Number 744270-00-6

  • Empirical Formula (Hill Notation) C18H19N3S

  • Molecular Weight 309.43

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
Quality Level   100
assay   ≥95% (HPLC)
form   powder
color   white to brown
solubility   DMSO: 5 mg/mL, clear (warmed)
storage temp.   room temp

Description

General description

The gene STAT3 (signal transducer and activator of transcription 3) is mapped to human chromosome 17q21. The protein contains a SH2 (src homology 2) domain.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

ML116 is a potent and selective inhibitor of STAT3 (signal transducer and activator of transcription 3) phosphorylation. ML116 potently inhibits growth and induces cell death of rodent and human glioma cells. ML116 is inactive against the related STAT1 and NFkB anti-targets.

STAT3 is a transcription factor which is activated by cytokines and growth factors. It is oncogenic and is present in various cancers, such as breast, prostate, renal cell, melanoma, ovarian, lung, leukemia, lymphoma and myelomas. It is associated with cellular growth, survival and malignancy.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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