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SML1602 Sigma-Aldrich

RQ-00203078

≥98% (HPLC)

Synonym: 4-(N-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid, 4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]-benzoic acid

  • CAS Number 1254205-52-1

  • Empirical Formula (Hill Notation) C21H13ClF6N2O5S

  • Molecular Weight 554.85

  •  MDL number MFCD29049510

  •  PubChem Substance ID 329825488

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Calcium Channel Modulators, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 25 mg/mL, clear
storage temp.   2-8°C
SMILES string   ClC1=CC(C(F)(F)F)=CN=C1N(S(C2=CC=C(C(O)=O)C=C2)(=O)=O)CC3=CC=C(OC(F)(F)F)C=C3
InChI   1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32)
InChI key   IJGQFZYYEHCCIZ-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

RQ-00203078 is an orally available potent and selective TRPM8 antagonist that potently reduces cation currents induced by menthol and other TRPM8 agonists. RQ-00203078 inhibits HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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