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SML1613 Sigma-Aldrich

CC-401 dihydrochloride

≥95% (HPLC)

Synonym: 1-[5-(1H-1,2,4-Triazol-5-yl)-1H-indazol-3-yl]-3-(2-piperidinoethoxy)benzene dihydrochloride, 3-(3-(2-(Piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole dihydrochloride, 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-iIndazole dihydrochloride, CC 401, CC401, CID 10430360

  • Empirical Formula (Hill Notation) C22H24N6O · 2HCl

  • Molecular Weight 461.39

  •  MDL number MFCD21364765

  •  PubChem Substance ID 329825499

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   OIBVXKYKWOUGAO-UHFFFAOYSA-N
assay   ≥95% (HPLC)
form   powder
color   white to beige
solubility   H2O: 10 mg/mL, clear
storage temp.   −20°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CC-401 is a cell penetrant, potent and selective c-Jun N terminal kinase (JNK) inhibitor that blocks JNK signaling in the rat obstructed kidney and inhibits renal fibrosis in the unilateral ureteral obstruction model. CC-401 in combination with chemotherapy exhibits synergism in colon cancer cell lines.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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