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SML1623 Sigma-Aldrich

MSP-3

≥98% (HPLC)

Synonym: N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide

  • CAS Number 1820968-63-5

  • Empirical Formula (Hill Notation) C16H19NO3S

  • Molecular Weight 305.39

  •  PubChem Substance ID 329825508

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Calcium Channel Modulators, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   oil
color   white to beige
storage temp.   room temp
SMILES string   O=C(NCC1=CC=C(O)C(OC)=C1)CCCC2=CC=CS2
InChI   1S/C16H19NO3S/c1-20-15-10-12(7-8-14(15)18)11-17-16(19)6-2-4-13-5-3-9-21-13/h3,5,7-10,18H,2,4,6,11H2,1H3,(H,17,19)
InChI key   HCUVEUVIUAJXRB-UHFFFAOYSA-N

Description

Biochem/physiol Actions

MSP-3 is a Transient Receptor Potential Vanilloid Type-1 (TRPV1) channel agonist with antioxidant and neuroprotective activity. MSP-3 activated TRPV1 channels with similar efficacy as compared to capsaicin (EC50 = 870 nM). It protected a keratinocyte cell line from oxidative stress damage with more efficacy than capsaicin and prevented the damage caused by H2O2 in differentiated human neuroblastoma cell lines as well as in rat cortical slices.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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