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SML1712 Sigma-Aldrich

SBC-115076

≥98% (HPLC)

Synonym: 1,5-Dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-2H-pyrrol-2-one

  • CAS Number 489415-96-5

  • Empirical Formula (Hill Notation) C31H33N3O5

  • Molecular Weight 527.61

  •  MDL number MFCD03296540

  •  PubChem Substance ID 329826034

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cholesterol and Cholesterol Metabolism,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   −20°C
SMILES string   CC1=CC(C(C(C(C2=CC=NC=C2)N3CCCN4CCOCC4)=C(O)C3=O)=O)=CC=C1OCC5=CC=CC=C5

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

SBC-115076 is an inhibitor of PCSK9 (proprotein convertase subtilisin-kexin 9). PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. SBC-115076 was shown to inihbit PCSK9, blocking LDLR degradation in HEK293T cells expressing PCSK9 and to increase the uptake of LDL by liver cells in vitro. SBC-115076 lowered cholesterol levels in mice fed a high fat diet.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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