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SML1736 Sigma-Aldrich

Nelarabine

≥98% (HPLC)

Synonym: 2-amino-9-β-D-arabinofuranosyl-6-methoxy-9H-purine, 506U78, 506U, 9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine, Arranon, Atriance, GW-506U78

  • CAS Number 121032-29-9

  • Empirical Formula (Hill Notation) C11H15N5O5

  • Molecular Weight 297.27

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   H2O: 5 mg/mL, clear (warmed)
storage temp.   2-8°C

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Nelarabine is an antineoplastic purine nucleoside analog used in T-cell acute lymphoblastic leukemia. It is a pro-drug of Ara-G, which is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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