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SML1737 Sigma-Aldrich

Beraprost sodium

≥98% (HPLC)

Synonym: 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta(b)benzofuran-5-butanoic acid sodium salt, Procyclin, TRK 100

  • CAS Number 88475-69-8

  • Empirical Formula (Hill Notation) C24H29O5 · Na

  • Molecular Weight 420.47

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Properties

Related Categories Anticoagulants, Arachidonic Acid Cascade, B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
assay   ≥98% (HPLC)
form   powder
storage condition   protect from light
color   white to beige
solubility   H2O: 20 mg/mL, clear
storage temp.   −20°C

Description

Packaging

1, 5 mg in glass bottle

Biochem/physiol Actions

Beraprost sodium is a chemically stable analog of prostacyclin PGI2. As other prostanoids, beraprost is a potent vasodilator and possesses antithrombotic, antiproliferative and anti-inflammatory properties. Beraprost sodium activates prostaglandin I (IP) receptor, which is coupled with Gs proteins and activates adenylate cyclase. It has been studied for the treatment of pulmonary hypertension.

Beraprost sodium is used as a therapeutic agent for chronic artery obstructions or primary pulmonary hypertension. In individuals with coronary artery disease, beraprost sodium helps to reduce oxidative stress and developed forearm endothelium dependent vasodilation.

General description

Beraprost sodium is an orally active prostacyclin analog.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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