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SML1746 Sigma-Aldrich

GS87

≥95% (HPLC)

Synonym: 4-[5-[[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G,
assay   ≥95% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 10 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

GS87 is a highly specific GSK3 (glycogen synthase kinase 3) inhibitor that induces extensive differentiation of AML cells. GS87 potently inhibits growth of AML cells in mice with little effect on normal bone marrow cells. GS87 causes terminal differentiation of AML cells.

GS87 regulates target proteins, that participates in the multiplication and differentiation of cells, much efficiently than lithium and SB. It helps to initiate mitogen-activated protein kinase (MAPK) signaling, that is required for its differentiation activity. GS87 is considered as a candidate for clinical acute myeloid leukemia (AML) differentiation therapy.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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