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SML1752 Sigma-Aldrich

LF3

≥98% (HPLC)

Synonym: N-[4-(Aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)-1-piperazinecarbothioamide

  • CAS Number 664969-54-4

  • Empirical Formula (Hill Notation) C20H24N4O2S2

  • Molecular Weight 416.56

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   −20°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

LF3 is a potent inhibitor of Wnt/β-catenin signaling that suppresses cancer cells motility, cell-cycle progression, and the overexpression of Wnt target genes. LF3 is a potent and specific antagonist of the interaction between β-catenin and the transcription factor TCF4. LF3 blocks self-renewal of cancer stem cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
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